A target without a molecule is only an observation. A molecule without a target is only a compound.

SilicoScientia was founded in Bengaluru in 2023 to close a gap that slows almost every discovery programme. Biology identifies a target. Chemistry has to find a molecule. Between the two sit different tools, different file formats and different specialists, and results rarely travel back the other way. Work that should take weeks takes months, and much of it cannot be repeated.

We set out to build one environment that holds both halves of the problem. OmicsXplore carries sequencing data through to ranked, evidence-linked targets. SilicoXplore carries those targets through generative design, docking, molecular dynamics and free-energy calculation to a short list of candidate molecules. Both run in the browser, need no coding or installation, and record every parameter, engine version and log, so a result can be reproduced years later by someone who was not there.

We built the technologies for our own research first, and we still use them that way. Our first papers appeared in 2024. The paper introducing SilicoXplore followed in 2026, applying the full cascade to New Delhi metallo-β-lactamase-1, an enzyme that defeats nearly the entire β-lactam class and for which no inhibitor has yet reached the clinic.

Incubated at C-CAMP and working with collaborators in India and abroad, we now make the same technologies available to the research groups and companies running programmes of their own.